Novel approaches for inhibition of Mucus hypersecretion in asthma

Anurag, Agrawal ; Ulaganathan, Mabalirajan ; Arjun, Ram ; Balaram, Ghosh (2007) Novel approaches for inhibition of Mucus hypersecretion in asthma Recent Patents on Inflammation & Allergy Drug Discovery, 1 (3). pp. 188-192. ISSN 1872-213X

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Many obstructive airway disorders such as cystic fibrosis, asthma, and chronic obstructive pulmonary disease (COPD) are characterized by mucous metaplasia of the airway epithelium and chronic mucus hypersecretion. Airway occlusion by mucus plugging has been reported in many cases of fatal asthma and conventional mucolytic therapies have been unable to significantly affect mucus-related airway obstruction. Recently, for the first time, direct evidence was presented for improvement of mucus related airway obstruction in a murine model of asthma, highlighting the potential usefulness of therapeutically targeting mucus hypersecretion. We review the emerging targets for inhibition of mucus hypersecretion and discuss some of the recent published scientific literature and patent applications in this field, to provide a framework for further drug discovery in mucus modulation.

Item Type:Article
Source:Copyright of this article belongs to Bentham Science Publishers.
Keywords:Asthma; COPD; Mucin; Airway Inflammation; Airway Hyperresponsiveness
ID Code:89945
Deposited On:02 May 2012 13:47
Last Modified:02 May 2012 13:47

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