Inducible Nitric Oxide Synthase (iNOS): role in asthma pathogenesis

Batra, Jyotsna ; Chatterjee, Rajshekhar ; Ghosh, Balaram (2007) Inducible Nitric Oxide Synthase (iNOS): role in asthma pathogenesis Indian Journal of Biochemistry & Biophysics, 44 (5). pp. 303-309. ISSN 0301-1208

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Asthma is one of the most common chronic inflammatory disorder of the airways of the lungs, affecting more than 300 million people all over the world. Nitric oxide (NO) is endogenously produced in mammalian airways by nitric oxide synthase (NOS) and is known to regulate many aspects of human asthma, including the modulation of airway and vascular smooth muscle tone and the inflammation. Asthmatic patients show an increased expression of inducible nitric oxide synthase (iNOS) in airway epithelial cells and an increased level of NO in exhaled air. Using various NO inhibitors (non-specific or iNOS-specific) and gene knock-out experiments, controversial results have been obtained regarding iNOS's beneficial and deleterious effects in the disease. In the present review, we have attempted to summarize the results of these experiments and also the genetic studies being undertaken to understand the role of iNOS in asthma. It is argued that extensive biochemical, clinical and genetic studies will be required to assess the precise role of NO in the asthma. This may help in designing selective and more potent iNOS inhibitors and NO donors for developing novel therapeutics for the asthma patients.

Item Type:Article
Source:Copyright of this article belongs to National Institute of Science Communication and Information Resources.
Keywords:iNOS; Asthma; Nitric Oxide; NOS Inhibitor; Gene
ID Code:89944
Deposited On:02 May 2012 13:46
Last Modified:02 May 2012 13:46

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