Marsh, David G. ; Neely, John D. ; Breazeale, Daniel R. ; Ghosh, Balaram ; Freidhoff, Linda R. ; Schou, Carsten ; Beaty, Terri H. (1995) Genetic basis of IgE responsiveness: relevance to the atopic diseases International Archives of Allergy and Immunology, 107 (1-3). pp. 25-28. ISSN 1018-2438
Full text not available from this repository.
Official URL: http://content.karger.com/ProdukteDB/produkte.asp?...
Related URL: http://dx.doi.org/10.1159/000236920
Abstract
Genetic analysis of 170 subjects in 11 extended Amish families revealed evidence for linkage of five markers in chromosome 5q31.1 with a gene controlling total serum IgE levels. No linkage was found between these markers and specific IgE antibody levels. Analysis of total IgE within a subset of 128 IgE-antibody-negative sib pairs confirmed evidence for linkage to 5q31.1, especially IL4 (p = 4 × 10--6). These and other data suggest that IL4 or a nearby gene regulates IgE production in a non-antigen-specific (noncognate) fashion and provide evidence for a possible link between asthma and the IL4 gene.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to S. Karger AG. |
| Keywords: | Ige Gene; 1l4; Asthma; Genetic Analysis; Noncognate Ige Production |
| ID Code: | 89936 |
| Deposited On: | 02 May 2012 13:27 |
| Last Modified: | 02 May 2012 13:27 |
Repository Staff Only: item control page
