Chandrasekhar, Vadapalli ; Athimoolam, Arunachalampillai ; Krishnan, Venkatasubbaiah ; Azhakar, Ramachandran ; Madhavaiah, C. ; Verma, Sandeep (2005) A copper-metalated, hybrid inorganic-organic polymer as an oxidative nuclease European Journal of Inorganic Chemistry, 2005 (8). pp. 1482-1486. ISSN 1434-1948
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Official URL: http://onlinelibrary.wiley.com/doi/10.1002/ejic.20...
Related URL: http://dx.doi.org/10.1002/ejic.200400727
Abstract
This study describes nucleolytic activity of a copper-metalated, multisite-coordinating, hybrid polymer CPPL-Cu under oxidative conditions. Rapid relaxation of supercoiled plasmid DNA was observed and mechanistic probing by chemical and enzymatic assays revealed involvement of singlet-oxygen-derived reactive species. The heterogeneous nature of the catalyst allowed a facile recycling of the artificial nuclease.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to John Wiley and Sons, Inc. |
| Keywords: | Chemical Nucleases; Phosphazenes; Pendant Polymers; Copper Complexes; Phosphate Ester Hydrolysis; Heterogeneous Catalysis |
| ID Code: | 8992 |
| Deposited On: | 29 Oct 2010 12:04 |
| Last Modified: | 11 Jul 2012 17:48 |
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