Allu, Suresh ; Molleti, Nagaraju ; Panem, Ramachandrarao ; Singh, Vinod K. (2011) Enantioselective organocatalytic Aldol reaction of unactivated ketones with isatins Tetrahedron Letters, 52 (32). pp. 4080-4083. ISSN 0040-4039
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Official URL: http://www.sciencedirect.com/science/article/pii/S...
Related URL: http://dx.doi.org/10.1016/j.tetlet.2011.05.013
Abstract
Enantioselective organocatalytic direct aldol reaction of unactivated ketones with various isatin derivatives was developed using cinchonine based urea ligand employing a noncovalent catalysis mechanism. Using this protocol we can access functionalized 3-alkyl-3-hydroxyindolin-2-ones in high yields with good to excellent enantioselectivities.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| Keywords: | Organocatalysis; Thiourea; Isatin; Enamine Mechanism; 3-alkyl-3-hydroxyindolin-2-ones |
| ID Code: | 89729 |
| Deposited On: | 30 Apr 2012 14:31 |
| Last Modified: | 30 Apr 2012 14:31 |
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