Immune response to hepatitis B virus surface antigen peptides during HBV infection

Mishra, A. ; Durgapal, H. ; Manivel, V. ; Acharya, S. K. ; Rao, K. V. ; Panda, S. K. (1992) Immune response to hepatitis B virus surface antigen peptides during HBV infection Clinical and Experimental Immunology, 90 (2). pp. 194-198. ISSN 0009-9104

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Antibody responses of patients with acute (n = 73), fulminant (n = 30) and chronic (n = 51) hepatitis B virus (HBV) infection as well as recovered individuals (n = 7) were studied against three synthetic peptides, Pre-S1 amino acids (aa. 12-32), Pre-S2 amino acids (aa. 120-145), and S amino acids (aa. 124-147) of the envelope region (HBsAg). T cell blastogenic response was investigated in a proportion of the patients (27 acute, nine fulminant, 13 chronic hepatitis and seven recovered individuals) along with seven HBV vaccinated and three normal individuals. The presence of T cell response against S peptide was observed in all the cases (9/9, 100%) during early acute hepatitis. This was suppressed during late stages (8/18, 44%) followed by partial reversal during recovery (5/7, 71%). T cell response and antibodies to Pre-S1 and Pre-S2 peptides were present only in one-third of the patients throughout these periods. The T cell blastogenic response as well as antibody reactivity against these peptides were absent and minimal in chronic hepatitis. Immune response against envelope protein appears to play a major role in acute hepatic injury due to HBV infection and help in virus clearance.

Item Type:Article
Source:Copyright of this article belongs to John Wiley and Sons.
ID Code:89705
Deposited On:30 Apr 2012 14:36
Last Modified:03 Jul 2012 07:54

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