Centpropazine affinity to cortical noradrenergic receptors and effect on their responsiveness in the rat

Abstract

We have studied the in-vitro effect of centpropazine on cerebral cortical noradrenergic receptors measured as the accumulation of second messengers, cyclic AMP and inositol phosphate, stimulated by noradrenaline, and the binding to α₁- and β-adrenoceptors. Centpropazine inhibited inositol phosphate, but not the cyclic AMP accumulation in the cerebral cortical slices of the rat. It moderately antagonized the specific binding of [³H]prazosin but did not affect the specific binding of the β-adrenoceptor ligand, [³H]CGP 12177, to cerebral cortical membranes.