Profile and prevalence of aspirin resistance in Indian patients with coronary artery disease

Sadiq, P. A. ; Puri, A. ; Dixit, M. ; Ghatak, A. ; Dwivedi, S. K. ; Narain, V. S. ; Saran, R. K. ; Puri, V. K. (2005) Profile and prevalence of aspirin resistance in Indian patients with coronary artery disease Indian Heart Journal, 57 (6). pp. 658-661. ISSN 0019-4832

Full text not available from this repository.

Official URL: http://indianheartjournal.com/archives.html

Abstract

Background: Aspirin resistance is considered to be an enigma and the data available on aspirin resistance is scarce. This study was initiated to prospectively evaluate the prevalence of aspirin resistance in patients with stable coronary artery disease by using an established method of optical platelet aggregation. Methods and Results: We studied 50 patients who were on 150 mg of aspirin for the previous 7 days. Fasting blood samples were assessed using optical platelet aggregation (Chronolog Corp, USA). The mean platelet aggregation with 10 microm of adenosine diphosphate in our patient group was 49.42 +/- 23.29% and with 0.5 mg/ ml of arachidonic acid it was 13.58 +/- 21.40%. Aspirin resistance was defined as a mean aggregation of < or =70% with 10 microm of adenosine diphosphate and a mean aggregation of < or =20% with 0.5 mg/ml of arachidonic acid. Aspirin semi responders were defined as those meeting only one of the criteria. Based on these criteria, 2.08% patients were found to be aspirin-resistant, 39.58% were aspirin semi responders and 58.33% were aspirin responders. Females tended to be more aspirin semi responsive (p = 0.08). All other parameters tested, namely, age, smoking, diabetes mellitus, hypertension, obesity, lipids, hemoglobin, platelet count, ejection fraction and drug intake did not show any statistically significant difference among the groups. Thus, in our group 41.66% patients showed inadequate response to aspirin. Conclusions: This study shows that aspirin resistance and aspirin semi responsiveness do occur in the Indian patients and there are no reliable clinical predictors for this condition. The diagnosis therefore relies primarily on laboratory tests.

Item Type:Article
Source:Copyright of this article belongs to Cardiological Society of India.
ID Code:89081
Deposited On:30 Mar 2012 10:38
Last Modified:30 Mar 2012 10:38

Repository Staff Only: item control page