Sashidhara, Koneni V. ; Kumar, Abdhesh ; Kumar, Manoj ; Singh, S. ; Jain, Manish ; Dikshit, Madhu (2011) Synthesis of novel 3-carboxamide-benzocoumarinderivatives as orally active antithrombotic agents Bioorganic & Medicinal Chemistry Letters, 21 (23). pp. 7034-7040. ISSN 0960-894X
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Official URL: http://www.sciencedirect.com/science/article/pii/S...
Related URL: http://dx.doi.org/10.1016/j.bmcl.2011.09.100
Abstract
In an effort to develop potent antithrombotic agents, a series of novel 3-carboxamide-benzocoumarin derivatives were synthesized and screened for their in vivo antithrombotic activity. Among 20 compounds tested, the compound 12b showed the most promising antithrombotic activity which was comparable with clinically used aspirin or warfarin, but, at variance with these standard drugs, 12b did not exhibit the increased bleeding time, suggesting its potential as a novel antithrombotic agent.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| Keywords: | Synthesis; 3-carboxamide-benzocoumarins; Antithrombotic Activity; Bleeding Time; Aspirin; Warfarin |
| ID Code: | 89058 |
| Deposited On: | 30 Mar 2012 10:45 |
| Last Modified: | 30 Mar 2012 10:45 |
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