Nicotinamide administration alters the activities of hepatic microsomal mixed function oxidases

Batra, J. K. ; Raj, H. G. ; Venkitasubramanian, T. A. (1980) Nicotinamide administration alters the activities of hepatic microsomal mixed function oxidases Cellular and Molecular Life Sciences, 36 (11). p. 1311. ISSN 1420-682X

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Official URL: http://www.springerlink.com/content/qv350542100470...

Related URL: http://dx.doi.org/10.1007/BF01969607

Abstract

Systemic action of nicotinamide significantly alters the activities of hepatic drug metabolizing enzymes. Male rats injected with nicotinamide have reduced levels of cytochrome P450, demethylases and aniline hydroxylase. The changes appear to be sex-dependent since in the case of female rats activities of p-nitroanisole-o-demethylase and aniline hydroxylase are enhanced whereas cytochrome P450 content remains unaltered.

Item Type:Article
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ID Code:88900
Deposited On:30 Mar 2012 06:43
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