Benzo(a)pyrene hydroxylase activity in human bronchial mucus

Kapoor, A. ; Batra, J. K. ; Luthra, U. K. ; Jain, R. C. ; Venkitasubramanian, T. A. ; Raj, H. G. (1986) Benzo(a)pyrene hydroxylase activity in human bronchial mucus European Journal of Drug Metabolism and Pharmacokinetics, 11 (1). pp. 33-37. ISSN 0398-7639

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Sputum collected from patients with respiratory diseases were examined for presence of benzo(a)pyrene hydroxylase (BPH) activity. The human bronchial mucus used in these studies had significant capability to metabolize benzo(a)pyrene. Clarification of the sputum by agents such as N-acetylcysteine or pancreatin in presence of antibiotics was found to be essential for the detection of BPH activity.In vitro incubation of the clarified human bronchial mucus with benzoflavone caused inhibition, while 7,8-dimethylbenzanthracene induced BPH enzyme activity.

Item Type:Article
Source:Copyright of this article belongs to Springer.
Keywords:Benzo(a)pyrene; Carcinogen; Lung; Bronchial Mucus; Sputum
ID Code:88897
Deposited On:30 Mar 2012 06:43
Last Modified:30 Mar 2012 06:43

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