Predominance of ancestral lineages of Mycobacterium tuberculosis in India

Cristina Gutierrez, M. ; Ahmed, Niyaz ; Willery, Eve ; Narayanan, Sujatha ; Hasnain, Seyed E. ; Chauhan, Devendra S. ; Katoch, Vishwa M. ; Vincent, Véronique ; Locht, Camille ; Supply, Philip (2006) Predominance of ancestral lineages of Mycobacterium tuberculosis in India Emerging Infectious Diseases, 12 (9). pp. 1367-1374. ISSN 1080-6059

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Although India has the highest prevalence of tuberculosis (TB) worldwide, the genetic diversity of Mycobacterium tuberculosis in India is largely unknown. A collection of 91 isolates originating from 12 different regions spread across the country were analyzed by genotyping using 21 loci with variable-number tandem repeats (VNTRs), by spoligotyping, by principal genetic grouping (PGG), and by deletion analysis of M. tuberculosis-specific deletion region 1. The isolates showed highly diverse VNTR genotypes. Nevertheless, highly congruent groupings identified by using the 4 independent sets of markers permitted a clear definition of 3 prevalent PGG1 lineages, which corresponded to the "ancestral" East African-Indian, the Delhi, and the Beijing/W genogroups. A few isolates from PGG2 lineages and a single representative of the presumably most recent PGG3 were identified. These observations suggest a predominance of ancestral M. tuberculosis genotypes in the Indian subcontinent, which supports the hypothesis that India is an ancient endemic focus of TB.

Item Type:Article
Source:Copyright of this article belongs to Centers for Disease Control and Prevention.
ID Code:88586
Deposited On:29 Mar 2012 09:42
Last Modified:16 Jul 2012 08:34

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