Adaptive and inflammatory immune responses in patients infected with strains of Vibrio parahaemolyticus

Qadri, Firdausi ; Alam, Muhammad Shamsul ; Nishibuchi, Mitsuaki ; Rahman, Taufiqur ; Alam, Nur Haque ; Chisti, Jobayer ; Kondo, Seiichi ; Sugiyama, Junichi ; Bhuiyan, Nurul Amin ; Mathan, Minnie M. ; Sack, David A. ; Balakrish Nair , G. (2003) Adaptive and inflammatory immune responses in patients infected with strains of Vibrio parahaemolyticus The Journal of Infectious Diseases, 187 (7). pp. 1085-1096. ISSN 0022-1899

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Official URL: http://jid.oxfordjournals.org/content/187/7/1085.s...

Related URL: http://dx.doi.org/10.1086/368257

Abstract

In patients with diarrhea caused by Vibrio parahaemolyticus antibody-secreting cell responses to thermostable direct hemolysin (TDH), lipopolysaccharide (LPS), and whole-cell bacteria were seen. TDH- and LPS-specific responses were seen in serum samples, and immunoglobulin A antibody responses were observed in stool. Levels of C-reactive protein and nitric oxide metabolites increased in the systemic circulation at the onset of illness. Tumor necrosis factor-a and lactoferrin levels were high during the acute stage in mucosal secretions and in plasma, whereas interleukin-1β levels were high only in mucosal secretions. Duodenal and rectal biopsy specimens obtained at the onset of illness showed an acute inflammatory response. The lamina propria showed edema, congestion of blood vessels, and hemorrhage, with an increase in levels of polymorphonuclear neutrophils and macrophages. Strains belonging to different serotypes exhibited varying resistance to killing by serum; the O8:K21 strain was most sensitive. Infection with V. parahaemolyticus results in B cell responses and an acute inflammatory response that is self-limiting

Item Type:Article
Source:Copyright of this article belongs to University of Chicago Press.
ID Code:88290
Deposited On:27 Mar 2012 12:53
Last Modified:27 Mar 2012 12:53

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