The role of protein synthesis in regulation of oestradiol-17β in the pro-oestrous hamster

Saidapur, S. K. ; Greenwald, G. S. (1981) The role of protein synthesis in regulation of oestradiol-17β in the pro-oestrous hamster The Journal of the Society for Reproduction and Fertility, 62 . pp. 379-384. ISSN 1741-7899

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Official URL: http://www.reproduction-online.org/content/62/2/37...

Related URL: http://dx.doi.org/10.1530/jrf.0.0620379

Abstract

Summary. Injection (s.c.) of 2 mg cycloheximide at 14:00 h on the day of pro-oestrus prevented the normal rise in serum progesterone and significantly lowered progesterone levels at 15:00 h. Values then rose but only to approximately half of the control values between 16:00 h and 19:00 h. Oestradiol levels also decreased drastically by 15:00 h but were significantly higher in cycloheximide-treated animals until 19:00 h. FSH and LH concentrations were not affected when cycloheximide was given at 14:00 h but treatment at 10:00 h resulted in generally lower values. Animals treated with cycloheximide at 14:00 h failed to ovulate (N = 9), but simultaneous injection of 50 µg progesterone restored ovulation in 50% of the treated animals. In contrast, hamsters injected with cycloheximide at 10:00 h ovulated the next morning, suggesting that protein synthesis essential for ovulation is limited to the first 4-5 h after the release of LH.

Item Type:Article
Source:Copyright of this article belongs to Society for Reproduction and Fertility.
ID Code:88178
Deposited On:27 Mar 2012 07:51
Last Modified:27 Mar 2012 07:51

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