Phylogeny of the insect homeobox gene (HOX) cluster

Dhawan, Sangeeta ; Gopinathan, K. P. (2005) Phylogeny of the insect homeobox gene (HOX) cluster Genomics Proteomics Bioinformatics, 3 (1). pp. 42-46. ISSN 1672-0229

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The homeobox (Hox) genes form an evolutionarily conserved family encoding tran- scription factors that play major roles in segmental identity and organ specification across species. The canonical grouping of Hox genes present in the HOM-C cluster of Drosophila or related clusters in other organisms includes eight \typical" genes, which are localized in the order labial (lab), proboscipedia (pb), Deformed (Dfd), Sex combs reduced (Scr), Antennapedia (Antp), Ultrabithorax (Ubx), abdominalA (abdA), and AbdominalB (AbdB). The members of Hox cluster are expressed in a distinct anterior to posterior order in the embryo. Analysis of the relatedness of different members of the Hox gene cluster to each other in four evolutionarily di- verse insect taxa revealed that the loci pb/Dfd and AbdB, which are farthest apart in linkage, had a high degree of evolutionary relatedness, indicating that pb/Dfd type anterior genes and AbdB are closest to the ancestral anterior and posterior Hox genes, respectively. The greater relatedness of other posterior genes Ubx and abdA to the more anterior genes such as Antp and Scr suggested that they arose by gene duplications in the more anterior members rather than the posterior AbdB.

Item Type:Article
Source:Copyright of this article belongs to Beijing Genomics Institute (BGI), China.
Keywords:Evolution; Homeodomain; Hox Genes; Insects; Phylogeny
ID Code:88115
Deposited On:23 Jun 2012 14:07
Last Modified:19 May 2016 03:08

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