Fertility and unilateral undescended testis in the rat model II

Srinivas, M. ; Agarwala, S. ; Datta Gupta, S. ; Das, S. N. ; Shaha, C. ; Mitra, D. K. (1998) Fertility and unilateral undescended testis in the rat model II Pediatric Surgery International, 13 (5-6). pp. 392-395. ISSN 0179-0358

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Official URL: http://www.springerlink.com/content/6u4p3kpv12walw...

Related URL: http://dx.doi.org/10.1007/s003830050347

Abstract

Continuing experimental work on the effect of experimentally created unilateral undescended testis (UL-UDT) in neonatal rats, this study examined the fertility and correlated it to contralateral (CL) testicular morphology, seminiferous tubular diameter (STD), DNA flowcytometry, and the presence of serum anti-sperm antibodies (ASA) at 120-135 days of age. In our previous reported work, the fertility of rats with UL-UDT at 65-80 days of age was the same as that of controls. In the present study the rats with UL-UDT had significantly reduced fertility (P<0.01) compared to controls, even though the Johnsen scores and mean STD of the CL testicular tissue were comparable. DNA flowcytometry demonstrated a significant decrease (P<0.001) in haploid cell population in the CL testicular tissue of rats with UL-UDT. Furthermore, the rats with UL-UDT who either received an immunosuppressive or in whom the UDT was excised early showed almost normal fertility and DNA histograms like those of controls. Significantly high titres of serum ASA were detected only in the group with UL-UDT when tested at 135 days of age. From these results, in combination with earlier results on similar work, it may be inferred that UL-UDT causes immunologically-mediated, progressive damage to the CL descended testis, leading to a decrease in fertility in rats.

Item Type:Article
Source:Copyright of this article belongs to Springer.
Keywords:Fertility; Unilateral Undescended Testis; DNA Flowcytometry; Anti-sperm Antibodies; Rats
ID Code:87478
Deposited On:19 Mar 2012 06:25
Last Modified:19 Mar 2012 06:25

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