Markad, Shankar D. ; Karanjule, Narayan S. ; Sharma, Tarun ; Sabharwal, Sushma G. ; Dhavale, Dilip D. (2006) Polyhydroxylated homoazepanes and 1-deoxy-homonojirimycin analogues: synthesis and glycosidase inhibition study Organic and Biomolecular Chemistry, 4 (19). pp. 3675-3680. ISSN 1477-0520
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Official URL: http://pubs.rsc.org/en/Content/ArticleLanding/2006...
Related URL: http://dx.doi.org/10.1039/B609000A
Abstract
The Johnson-Claisen rearrangement of D-gluco and L-ido-derived allylic orthoesters afforded γ,δ-unsaturated ester that on ester reduction, epoxidation, regioselective oxirane opening by sodium azide and hydrogenation led to sugar amino alcohols-immediate precursors for 1-deoxy-homonojirimycin 3a,b and polyhydroxylated homoazepanes 4a,b. Our synthetic approach and glycosidase inhibitory activity is reported.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Royal Society of Chemistry. |
| ID Code: | 87233 |
| Deposited On: | 16 Mar 2012 06:14 |
| Last Modified: | 19 Mar 2012 11:31 |
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