Organocatalytic stereoselective synthesis of passifloricin A

Kumar, Pradeep ; Pandey, Menaka ; Gupta, Priti ; Dhavale, Dilip D. (2012) Organocatalytic stereoselective synthesis of passifloricin A Organic and Biomolecular Chemistry, 10 (9). pp. 1820-1825. ISSN 1477-0520

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Official URL: http://pubs.rsc.org/en/content/articlelanding/2012...

Related URL: http://dx.doi.org/10.1039/C2OB06711K

Abstract

The enantioselective synthesis of passifloricin A has been achieved in high diastereomeric excess. The 1,3-polyol moiety was constructed by iterative proline-catalyzed sequential α-aminoxylation and Horner-Wadsworth-Emmons (HWE) olefination of aldehydes while the synthesis of lactone moiety was achieved by ring-closing metathesis (RCM).

Item Type:Article
Source:Copyright of this article belongs to Royal Society of Chemistry.
ID Code:87219
Deposited On:16 Mar 2012 06:16
Last Modified:19 Mar 2012 11:35

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