Antigen-specific early primary humoral responses modulate immunodominance of B cell epitopes

Vijayakrishnan, L. ; Kumar, V. ; Agrewala, J. N. ; Mishra, G. C. ; Rao, K. V. (1994) Antigen-specific early primary humoral responses modulate immunodominance of B cell epitopes The Journal of Immunology, 153 (4). pp. 1613-1625. ISSN 0022-1767

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Official URL: http://www.jimmunol.org/content/153/4/1613.short

Abstract

Accumulation of primary Abs against two distinct epitopes on a designed polypeptide, MEP-1, was examined. The early primary response was predominantly against a C-terminal epitope (MEP 77-100), although subsequent maturation established an epitope within the N-terminal half (MEP 17-31) as the immunodominant one. Inversion of immunodominance correlated with the inability of anti-MEP 77-100 B cells to interact productively with T cells, which consequently received reduced help. Interaction between epitope-specific B and T cells was found to be attenuated in the presence of early primary anti-MEP-1 antiserum, and the extent of inhibition was directly proportional to the level and affinity of epitope-specific Igs. Therefore, it seems that early primary Abs to a multideterminant Ag selectively down-regulate maturation of epitope-specific primary humoral responses.

Item Type:Article
Source:Copyright of this article belongs to American Association of Immunologists.
ID Code:86643
Deposited On:12 Mar 2012 13:49
Last Modified:12 Mar 2012 13:49

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