Macromolecular crystallography research at Trombay

Kannan, K. K. ; Chidambaram, R. (1983) Macromolecular crystallography research at Trombay Proceedings of the Indian Academy of Sciences - Chemical Sciences, 92 (4-5). pp. 497-507. ISSN 0253-4134

Full text not available from this repository.

Official URL:


Neutron diffraction studies of hydrogen positions in small molecules of biological interest at Trombay have provided valuable information that has been used in protein and enzyme structure model-building and in developing hydrogen bond potential functions. The new R-5 reactor is expected to provide higher neutron fluxes and also make possible smallangle neutron scattering studies of large biomolecules and bio-aggregates. In the last few years infrastructure facilities have also been established for macromolecular x-ray crystallography research. Meanwhile, the refinement of carbonic hydrases' and lysozyme structures have been carried out and interesting results obtained on protein dynamics and structure-function relationships. Some interesting presynaptic toxin phospholipases have also been taken up for study.

Item Type:Article
Source:Copyright of this article belongs to Indian Academy of Sciences.
Keywords:Protein Crystallography; Enzyme Mechanism; Neutron Diffraction; X-Ray Diffraction; Carbonic Anhydrase; Lysozyme; Presynaptic Toxins
ID Code:86264
Deposited On:08 Mar 2012 11:27
Last Modified:04 Apr 2012 10:09

Repository Staff Only: item control page