Inheritance of Indian childhood cirrhosis

Agarwal, S. S. ; Lahori, U. C. ; Mehta, S. K. ; Smith, D. G. ; Bajpai, P. C. (1979) Inheritance of Indian childhood cirrhosis Human Heredity: International Journal of Human and Medical Genetics, 29 (2). pp. 82-89. ISSN 0001-5652

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Detailed pedigree charts were prepared from 120 index patients suffering from Indian childhood cirrhosis (ICC). Of the 120 families, 84 were informative for segregation analysis. Since families were ascertained through patients who came to hospital for treatment, the data were analyzed according to a single-selection model. The observed segregation ratio for the entire data was significantly lower than the one expected under the hypothesis of autosomal recessive inheritance (p = < 0.005). On the other hand, the segregation data for families with at least two affected children (multiplex families) were compatible with autosomal recessive inheritance. On this basis, however, at least 50% of all the cases of ICC would have to be of nongenetic origin. Alternatively, analysis of the data by the Falconer method indicated that ICC could be of multifactorial origin with very strong genetic determination (over 85%).

Item Type:Article
Source:Copyright of this article belongs to Karger Publisher.
Keywords:Indian Childhood Cirrhosis; Segregation Analysis; Autosomal Recessive; Heritability Estimates
ID Code:86
Deposited On:17 Sep 2010 06:52
Last Modified:12 May 2011 04:14

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