Membrane-associated cytoskeleton and transbilayer phospholipid asymmetry

Gupta, C. M. (1990) Membrane-associated cytoskeleton and transbilayer phospholipid asymmetry Indian Journal of Biochemistry & Biophysics, 27 (6). pp. 365-367. ISSN 0301-1208

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Earlier studies have suggested that the membrane-associated cytoskeleton (membrane skeleton) in erythrocytes plays a major role in maintaining the transmembrane phospholipid asymmetry. But recently, it has been proposed that an ATP-dependent aminophospholipid pump is the sole determinant of this asymmetry in these cells. A critical analysis of the published data along with some unpublished results from the author's laboratory, however, indicate that both membrane skeleton and ATP-dependent aminophospholipid pump are required for maintaining the membrane phospholipid asymmetry in native erythrocytes.

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ID Code:85615
Deposited On:05 Mar 2012 06:41
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