Specific interactions of liposomes with PMN leukocytes upon incorporating tuftsin in their bilayers

Singhal, Arun ; Bali, Anu ; Jain, Rakesh K. ; Gupta, C. M. (1984) Specific interactions of liposomes with PMN leukocytes upon incorporating tuftsin in their bilayers FEBS Letters, 178 (1). pp. 109-113. ISSN 0014-5793

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Official URL: http://www.sciencedirect.com/science/article/pii/0...

Related URL: http://dx.doi.org/10.1016/0014-5793(84)81251-X

Abstract

Incorporation of tuftsin derivatives, Thr-Lys-Pro-Arg-NH-C18H37 or Thr-Lys-Pro-Arg-NH-(CH2)2-NH-COC15H31, into an egg phosphatidylcholine/cholesterol liposome bilayer led to significantly enhanced binding of the liposomes to PMN leukocytes at 37° C but not at 0° C. Under identical conditions, no such enhanced binding of the liposomes was observed with erythrocytes and lymphocytes. These results demon-strate that grafting of tuftsin on the liposome bilayer enables the liposome to recognize specifically the PMN leukocytes and to deliver its contents to these cells.

Item Type:Article
Source:Copyright of this article belongs to Elsevier Science.
Keywords:Drug Targeting; Liposome; Ligand-receptor Interaction; Tuftsin; Leukocyte; Endocytosis
ID Code:85607
Deposited On:05 Mar 2012 06:38
Last Modified:05 Mar 2012 06:38

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