Gupta, C. M. ; Bhaduri, A. P. ; Khanna, K. M. (1968) Drugs acting on CNS: Syntheses of 2-substituted & 2,3-disubstituted benzo( 6,7) quinazoline-4 -ones Indian Journal of Chemistry, 6 . pp. 621-623. ISSN 0019-5103
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Abstract
A series of 2-substituted and 2,3-disubstituted benzo(6,7)quinazoline-4-ones have been synthesized as possible CNS depressants. 2-Substituted products, viz. hydrazino, phenylhydrazino and amino, have been obtained by the reaction of 2-ethylthio-benzo(6,7) quinazolin-4-one with hydrazine, phenylhydrazine, and primary and secondary amines. The 2,3-disubstituted derivatives have been obtained by the reaction of 2-mercapto-3-phenyl-benzo(6,7)quinazoline- 4-one with appropriate alkyl, arylalkyl, dialkylamino-alkyl halides in the presence of alcoholic sodium hydroxide. Some of the compounds exhibit CNS-depressant activity at high dosage.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to National Institute of Science Communication and Information Resources. |
| Keywords: | CNS Depressants; Sodium Hydroxide; 2-substituted; 2,3-disubstituted |
| ID Code: | 85550 |
| Deposited On: | 05 Mar 2012 06:38 |
| Last Modified: | 05 Mar 2012 06:38 |
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