Regulation of expression of β-galactoside α2, 6-sialyltransferase in a rat tumor, zajdela ascitic hepatoma

Jain, Neeraj ; Sudhakar, Ch. ; Das, M. R. (1993) Regulation of expression of β-galactoside α2, 6-sialyltransferase in a rat tumor, zajdela ascitic hepatoma FEBS Letters, 317 (1-2). pp. 147-151. ISSN 0014-5793

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Official URL: http://linkinghub.elsevier.com/retrieve/pii/001457...

Related URL: http://dx.doi.org/10.1016/0014-5793(93)81511-W

Abstract

Tumor cell surface sialic acid levels determine a number of important properties governing cellular interactions and cell−cell communication. Towards understanding the mechanism of regulation of sialic acid levels upon cellular transformation, we have studied the regulation of expression of β-galactoside α2, 6-sialyltransferase in a rat tumor, the Zajdela ascitic hepatoma. We demonstrate distinct differences in the regulation of expression of the enzyme in the tumor cells as compared to normal liver cells. The expression of sialyltransferase is regulated both at the transcriptional and post-transcriptional level in a tissue-specific manner.

Item Type:Article
Source:Copyright of this article belongs to Elsevier Science.
Keywords:β-galactoside α2; 6-sialyltransferase; Zajdela Ascitic Hepatoma; Regulation of Expression; Sialic Acid Level
ID Code:8544
Deposited On:27 Oct 2010 06:18
Last Modified:16 May 2016 18:29

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