Fetal liver infusion in aplastic anaemia

Kochupillai, V. ; Sharma, S. ; Francis, S. ; Nanu, A. ; Mathew, S. ; Bhatia, P. ; Dua, H. ; Kumar, L. ; Aggarwal, S. ; Singh, S. ; al, et. (1987) Fetal liver infusion in aplastic anaemia Thymus, 10 (1-2). pp. 95-102. ISSN 0165-6090

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Forty patients with severe aplastic anaemia received an intravenous infusion of 0.004 to 11.1 × 10(8) (median: 8 × 10(8) hematopoietic cells prepared from the fetal livers of 8-32 week old abortuses. Five patients, who died within 15 days of fetal liver infusion, are excluded from analysis. Twenty-two of the 35 evaluable patients (62%) responded favourably. Six of the 7 patients with good response were alive after 9 to 44 months (median: m = 20); one died 106 months after fetal liver infusion due to renal lithiasis. Four of the 7 with moderate response were alive after 9 to 31 months; 3 died within 16 months. Of 8 patients with minimal response, one was lost to follow-up and the others died in 3.4 to 10 months (m = 6). Median survival of responders was 15.7 months. Bone marrow cellularity became normal in 12 patients following fetal liver infusion. In seven patients, there was a relapse; 6 regained a normal bone marrow cellularity after a second or third fetal liver infusion. These data strongly suggest a role of fetal liver infusion in inducing bone marrow recovery. Of 13 non-responders, 4 were lost to follow-up and 9 died within 20 days-4.3 months (m = 1.6). Fetal liver infusion appears to be an effective therapy in patients with severe aplastic anaemia.

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Deposited On:02 Mar 2012 07:26
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