Fast pseudo-periodic oscillation in the rat brain voltage-gated sodium channel α subunit

Majumdar, S. ; Sikdar, S. K. (2005) Fast pseudo-periodic oscillation in the rat brain voltage-gated sodium channel α subunit Journal of Membrane Biology, 208 (1). pp. 1-14. ISSN 0022-2631

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In the work reported here, we have investigated the changes in the activation and fast inactivation properties of the rat brain voltage-gated sodium channel (rNaν 1.2a) α subunit, expressed heterologously in the Chinese Hamster Ovary (CHO) cells, by short depolarizing prepulses (10 - 1000 ms). The time constant of recovery from fast inactivation (τfast) and steady-state parameters for activation and inactivation varied in a pseudo-oscillatory fashion with the duration and amplitude of a sustained prepulse. A consistent oscillation was observed in most of the steady-state and non-inactivating current parameters with a time period close to 225 ms, although a faster oscillation of time period 125 ms was observed in the τfast. The studies on the non-inactivating current and steady-state activation indicate that the phase of oscillation varies from cell to cell. Co-expression of the β1 subunit with the α subunit channel suppressed the oscillation in the charge movement per single channel and free energy of steady-state inactivation, although the oscillation in the half steady-state inactivation potential remained unaltered. Incidentally, the frequencies of oscillation in the sodium channel parameters (4-8 Hz) correspond to the theta component of network oscillation. This fast pseudo-oscillatory mechanism, together with the slow pseudo-oscillatory mechanism found in these channels earlier, may contribute to the oscillations in the firing properties observed in various neuronal subtypes and many pathological conditions.

Item Type:Article
Source:Copyright of this article belongs to Springer.
Keywords:Voltage Gated Sodium Channel; Weigh-ted Wavelet Analysis; Whole-cell Patch-clamp; Epilepsy; Oscillation
ID Code:84763
Deposited On:27 Feb 2012 13:45
Last Modified:27 Feb 2012 13:45

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