Chromosomal damage induced in human lymphocytes by low doses of D-T neutrons

Pohl-Ruling, J. ; Fischer, P. ; Lloyd, D. C. ; Edwards, A. A. ; Natarajan, A. T. ; Obe, G. ; Buckton, K. E. ; Bianchi, N. O. ; van Buul, P. P. W. ; Das, B. C. ; Daschil, F. ; Fabry, L. ; Kucerova, M. ; Leonard, A. ; Mukherjee, R. N. ; Mukherjee, U. ; Nowotny, R. ; Palitti, P. ; Polivková, Z. ; Sharma, T. ; Schmidt, W. (1986) Chromosomal damage induced in human lymphocytes by low doses of D-T neutrons Mutation Research Letters, 173 (4). pp. 267-272. ISSN 0165-7992

Full text not available from this repository.

Official URL:

Related URL:


Unstable chromosome aberrations induced by in vitro irradiation with zero plus seven low doses of 14.8 MeV D-T neutrons in the range 3.55-244 mGy have been analysed in human peripheral blood lymphocytes. In order to obtain the required large numbers of scored cells for such low doses, fourteen laboratories participated in the experiment. The dose responses for dicentrics, excess acentrics and total aberrations, fitted well to the Y = αD model. The α coefficient of yield for dicentrics, 1.60 ± 0.07 × 10-2 Gy-1, compares well with the values obtained in previous studies with D-T neutrons at somewhat higher doses. Results from a previous collaborative study using 250 kVp X-rays over a comparable dose range indicated the possible existence of a threshold below 50 mGy. In the present study there is no clear evidence for neutrons for such a threshold. However, the data were insufficient to permit the rejection of a possible threshold below ~10 mGy.

Item Type:Article
Source:Copyright of this article belongs to Elsevier Science.
ID Code:8460
Deposited On:27 Oct 2010 06:30
Last Modified:30 May 2011 08:22

Repository Staff Only: item control page