Kumar, Sachin ; Guleria, Randeep ; Mohan, Anant ; Singh, Vikas ; Ali, Ashraf ; Bharti, Alok C. ; Das, Bhudev C. (2010) Utility of plasma tumour necrosis factor-a and transforming growth factor-β1 as predictors of survival and treatment outcome in advanced non-small cell lung carcinoma Biomarkers, 15 (5). pp. 446-453. ISSN 1354-750X
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Official URL: http://informahealthcare.com/doi/abs/10.3109/13547...
Related URL: http://dx.doi.org/10.3109/1354750X.2010.485699
Abstract
We hypothesized that plasma level of tumour necrosis factor (TNF)-α and transforming growth factor (TGF)-β1 may be a potential tool for diagnosis, prognosis and prediction of treatment outcome in non-small cell lung carcinoma (NSCLC). Plasma levels of TNF-α and TGF-β1 were quantified in 100 NSCLC patients and 100 controls. Association of TNF-α and TGF-β 1 with response to therapy and survival was determined in 42 patients. An increased presence of TNF-α and TGF-β1 was observed in NSCLC compared with controls. TNF-α and TGF-α levels did not correlate with survival and response to chemotherapy. TNF-α and TGF-β1 do not appear to be reliable markers for predicting survival and response to therapy in advanced NSCLC.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Informa Healthcare. |
| Keywords: | Chemotherapy; Diagnosis; Prognosis; Response |
| ID Code: | 8445 |
| Deposited On: | 27 Oct 2010 06:32 |
| Last Modified: | 30 May 2011 07:12 |
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