T cell receptor (TCR) V gene usage in patients with systemic necrotizing vasculitis

Giscombe, R. ; Grunewald, J. ; Nityanand, S. ; Lefvert, A. K. (1995) T cell receptor (TCR) V gene usage in patients with systemic necrotizing vasculitis Clinical and Experimental Immunology, 101 (2). pp. 213-219. ISSN 0009-9104

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Official URL: http://onlinelibrary.wiley.com/journal/10.1111/%28...


Wegener's granulomatosis (WG) and polyarteritis nodosa (PAN) are systemic necrotizing vasculitides of unknown etiology. These disorders run a fatal course if untreated. T lymphocytes are implicated in the pathogenesis of WG, since they have been found to infiltrate affected organs, and sIL-2R correlates with disease activity. To elucidate further the role of T cells in necrotizing vasculitis, we have used a panel of 12 TCR V-specific MoAbs to investigate the number of cells expressing certain V alpha and V beta gene segments in the CD4+ and CD8+ subsets of altogether 11 patients with WG or PAN. In the group of patients, we found abnormal expansions of T cells using particular TCR V alpha or V beta gene products. These T cell expansions were more numerous, of a dramatically higher magnitude, and frequently more often found in the CD4 subset, compared with T cell expansions identified in healthy individuals. In long-term studies of the T cell expansions for up to 18 months, a heterogeneous pattern was revealed, with no obvious correlation to clinical features such as disease activity or treatment. Studies of TCR V gene usage in this group of patients may help in understanding the pathogenesis of necrotizing vasculitis, and in the identification of unknown antigens, and may open the possibility to a highly selective immunotherapy by targeting disease-mediating T cells.

Item Type:Article
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Deposited On:24 Feb 2012 13:04
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