HPV & HPV vaccination: issues in developing countries

Bharadwaj, Mausumi ; Hussain, Showket ; Nasare, Vilas ; Das, Bhudev C. (2009) HPV & HPV vaccination: issues in developing countries Indian Journal of Medical Research, 130 (3). pp. 327-333. ISSN 0971-5916

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Official URL: http://icmr.nic.in/ijmr/2009/september/0914.pdf


Cervical cancer is the second-most common cancer in women worldwide causing most cancer related deaths in women in developing countries including India. The most predominant etiological factor for cervical cancer is persistent infection of certain high-risk types of human papillomaviruses (HR-HPVs), while low-risk types are associated with benign cervical lesions and genital warts. In India, the most common (98%) oncogenic types are HPV types 16 and 18 with HPV 16 exclusively (80-90%) prevalent. Two recently developed virus-like particle (VLP) based prophylactic HPV vaccines, quadrivalent Gardasil (HPV 16/18/6/11) and Cervarix (HPV 16/18) offer great promise. Several other therapeutic vaccines are also in clinical trials and are yet to establish their efficacy. The use of already developed VLP vaccines in resource-poor regions is limited by several factors, most importantly the high cost of the vaccine. Therefore efforts are being made in India to develop cost-effective second-generation vaccines. Besides cost, there are several socio-cultural and ethical issues involved with the implementation of already developed vaccines including the acceptability of HPV vaccination by preadolescent girls and their parents in India.

Item Type:Article
Source:Copyright of this article belongs to Indian Council of Medical Research.
Keywords:Cervical Cancer; Human Papillomavirus (HPV); Issues in India; Prophylactic Vaccines; Therapeutic Vaccines
ID Code:8366
Deposited On:26 Oct 2010 11:39
Last Modified:30 May 2011 07:23

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