TNFα-308G/A polymorphism as a risk factor for HPV associated Cervical Cancer in Indian population

Kohaar, Indu ; Thakur, Nisha ; Salhan, Sudha ; Batra, Swaraj ; Singh, Veena ; Sharma, Anita ; Sodhani, Pushpa ; Das, B. C. ; Sarkar, Debi P. ; Bharadwaj, Mausumi (2007) TNFα-308G/A polymorphism as a risk factor for HPV associated Cervical Cancer in Indian population Cellular Oncology, 29 (3). pp. 249-256. ISSN 1570-5870

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Background: Investigation of the potential association of single nucleotide polymorphisms (SNPs) at -308 G/A and -238 G/A of Tumor necrosis factor a (TNFα) with susceptibility to HPV-16 associated cervical cancer in Indian women. Methods: The study included 165 histologically confirmed cases with 45 precancer and 120 cancer patients and an equal number (165) of healthy controls with normal cervical cytology. PCR-RFLP was employed to analyze TNFα promoter polymorphisms, which were confirmed by direct sequencing. Both patients and controls were screened for Human Papillomavirus (HPV) infection. Results: The frequency of -308 A allele in TNFα was significantly higher in cases compared with control subjects (21% in cases vs. 9% in controls; p<0.01), with an odds ratio of 2.7 (95% CI = 1.41-5.15). Also, women carrying A allele for this locus presented 3 times increased susceptibility to HPV 16 infection as evident from carrier genotype distribution between HPV positive cases and control subjects (24% in HPV positive cases vs. 9% in controls; p<0.01; OR = 3.1; 95% CI = 1.60-6.03). No such association was found for TNFα-238 (G/A) polymorphism with the risk of development of cervical cancer. Conclusion: It suggests that SNP at -308 (G/A) of TNFα promoter may represent an increased risk for HPV infection and development of cervical cancer in Indian women.

Item Type:Article
Source:Copyright of this article belongs to IOS Press.
Keywords:Tumor Necrosis Factor α (TNFα); Single Nucleotide Polymorphism; -308 Promoter Polymorphism; -238 Promoter Polymorphism; Cervical Precancer; Cervical Cancer; Human Papillomavirus; Genetic Susceptibility
ID Code:8349
Deposited On:26 Oct 2010 11:43
Last Modified:14 Jul 2012 06:07

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