SEB-induced signaling in macrophages leads to biphasic TNF-α

Ali Khan, Aslam ; Martin, Sunil ; Saha, Bhaskar (2008) SEB-induced signaling in macrophages leads to biphasic TNF-α Journal Of leukocyte Biology, 83 (6). pp. 1363-1369. ISSN 0741-5400

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Official URL: http://www.jleukbio.org/content/83/6/1363.short

Related URL: http://dx.doi.org/10.1189/jlb.1007686

Abstract

APCs express MHC-II molecules. Binding of enterotoxins to MHC-II generates a signal resulting in the production of TNF-α that mediates toxic shock syndrome. However, the signaling events that lead to TNF-α production in macrophages are not well understood. We, for the first time, demonstrate that binding of staphylococcal enterotoxin B to MHC-II results in activation of TNF-α -converting enzyme, epidermal growth factor receptor, p38MAPK, and NF-κB inducing biphasic TNF-α production. Paraformaldehyde-fixed, peptide-specific T cells also activate MHC-II signaling and TNF-α induction in peptide-pulsed macrophages. Our results reveal a novel MHC-II signaling and bidirectional macrophage-T cell interaction regulating macrophage functions. This knowledge may help to develop novel, macrophage-directed, therapeutic strategies.

Item Type:Article
Source:Copyright of this article belongs to Society for Leukocyte Biology.
Keywords:MHC Class-II Signaling ; Staphylococcal Enterotoxin B ; Superantigen ; APC-T Cell Interaction
ID Code:83130
Deposited On:16 Feb 2012 12:39
Last Modified:16 Feb 2012 12:39

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