CD40-Induced countercurrent conduits for tumor escape or elimination?

Murugaiyan, Gopal ; Martin, Sunil ; Saha, Bhaskar (2007) CD40-Induced countercurrent conduits for tumor escape or elimination? Trends In Immunology, 28 (11). pp. 467-473. ISSN 1471-4906

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Official URL: http://www.sciencedirect.com/science/article/pii/S...

Related URL: http://dx.doi.org/10.1016/j.it.2007.08.010

Abstract

CD40 - which is expressed on endothelial cells and antigen-presenting cells, such as B cells, macrophages and dendritic cells - is a glycoprotein receptor for T cell-expressed CD40-ligand. CD40 signaling leads to production of both pro-inflammatory and anti-inflammatory mediators. Some of these mediators, such as vascular endothelial growth factor, help in angiogenesis, forming new capillaries. Although these capillaries can function as conduits for tumor-cell metastasis, these same vessels can also be a gateway for entry of activated anti-tumor effector cells that eliminate tumors. How such countercurrent processes can be turned in favor of anti-tumor immunity remains to be shown.

Item Type:Article
Source:Copyright of this article belongs to Elsevier Science.
ID Code:83124
Deposited On:16 Feb 2012 12:39
Last Modified:16 Feb 2012 12:39

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