Kotha, Sambasivarao ; Kakali, Lahiri (2005) Post-assembly peptide modifications by chemical methods Current Medicinal Chemistry, 12 (7). pp. 849-875. ISSN 0929-8673
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Official URL: http://www.ingentaconnect.com/content/ben/cmc/2005...
Related URL: http://dx.doi.org/10.2174/0929867053507333
Abstract
The demand for peptide drugs is increasing and in this context, "post-assembly (or posttranslational) peptide modification strategies" by chemical manipulation of intact oligo-peptides has provided several analogues. Compounds prepared by this method are useful therapeutic molecules for structure activity studies. Herein, we describe various chemical methods such as cross-coupling reactions, cycloaddition reactions, radical reactions and ring-closing metathesis reactions that are useful for posttranslational peptide modifications.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Bentham Science Publishers. |
| Keywords: | Sequencing; Human Genome; Peptide; Oxidation; Biomimetic Cyclization; Crosscoupling Reactions; Photoaffinity |
| ID Code: | 82036 |
| Deposited On: | 09 Feb 2012 04:27 |
| Last Modified: | 09 Feb 2012 04:27 |
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