Post-assembly peptide modifications by chemical methods

Kotha, Sambasivarao ; Kakali, Lahiri (2005) Post-assembly peptide modifications by chemical methods Current Medicinal Chemistry, 12 (7). pp. 849-875. ISSN 0929-8673

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The demand for peptide drugs is increasing and in this context, "post-assembly (or posttranslational) peptide modification strategies" by chemical manipulation of intact oligo-peptides has provided several analogues. Compounds prepared by this method are useful therapeutic molecules for structure activity studies. Herein, we describe various chemical methods such as cross-coupling reactions, cycloaddition reactions, radical reactions and ring-closing metathesis reactions that are useful for posttranslational peptide modifications.

Item Type:Article
Source:Copyright of this article belongs to Bentham Science Publishers.
Keywords:Sequencing; Human Genome; Peptide; Oxidation; Biomimetic Cyclization; Crosscoupling Reactions; Photoaffinity
ID Code:82036
Deposited On:09 Feb 2012 04:27
Last Modified:09 Feb 2012 04:27

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