Biology of the HIV Nef protein

Das, Suman Ranjan ; Jameel, Shahid (2005) Biology of the HIV Nef protein Indian Journal of Medical Research, 121 . pp. 315-332. ISSN 0019-5340

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The accessory Nef protein is expressed by all primate lentiviruses - HIV-1, HIV-2 and simian immune deficiency virus (SIV). Its expression in the early stages of the viral life cycle ensures two basic attributes of HIV infection. These are T-cell activation and the establishment of a persistent state of infection. Nef has a positive effect on viral infection and replication by promoting the survival of infected cells. Its role in HIV persistence is based largely on the ability of Nef to downmodulate the surface levels of important molecules at the immune synapse. These include major histocompatibility complex-I (MHC I) and (MHC II) present on antigen-presenting cells (APCs) and target cells, and CD4 and CD28 present on helper T cells. In this review we present these biological properties of Nef from a mechanistic point of view, and relate them to the structural attributes and interactions of the Nef protein. A brief outline of the limited studies on Nef from Indian subtype C HIV-1 isolates is also presented.

Item Type:Article
Source:Copyright of this article belongs to Indian Council of Medical Research.
Keywords:Apoptosis; HIV-1; Immune Synapse; Nef; Signaling; T-cell Activation
ID Code:81917
Deposited On:08 Feb 2012 15:27
Last Modified:08 Feb 2012 15:27

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