Common aetiological agent for epidemic and sporadic non-A, non-B hepatitis

Chauhan, A. ; Dilawari, J. B. ; Chawla, Y. K. ; Ganguly, N. K. ; Kaur, U. ; Jameel, S. ; Sharma, M. L. (1992) Common aetiological agent for epidemic and sporadic non-A, non-B hepatitis The Lancet, 339 (8808). pp. 1509-1510. ISSN 0140-6736

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Official URL: http://www.sciencedirect.com/science/article/pii/0...

Related URL: http://dx.doi.org/10.1016/0140-6736(92)91267-C

Abstract

Enterovirus-like particles have been reported in the acute phase of both epidemic and sporadic non-A, non-B (NANB) hepatitis. To examine whether these particles were the causative agent in the two types of disease, 29 patients with acute viral hepatitis in a north Indian epidemic outbreak and 9 with sporadic acute disease were investigated. 25 (86%) of 29 patients with epidemic hepatitis and 5 (56%) of 9 with sporadic disease were diagnosed as having enterically-transmitted-NANB hepatitis by exclusion. Virus-like particles (VLP) of 30-34 nm were detected in stool of 1 patient with epidemic and 1 with sporadic hepatitis. The VLPs crossreacted serologically and a specific IgM response was seen in acute epidemic and sporadic serum samples. After inoculation with infected stool rhesus monkeys had a mild rise in liver enzymes, and bile samples contained VLPs. These results suggest that the aetiological agent in epidemic and sporadic disease is the same.

Item Type:Article
Source:Copyright of this article belongs to The Lancet.
ID Code:81892
Deposited On:08 Feb 2012 15:22
Last Modified:10 Jul 2012 05:39

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