Long-term effect of rosiglitazone and/or ramipril on the incidence of diabetes

Gerstein, H. C. ; Mohan, V. ; Avezum, A. ; Bergenstal, R. M. ; Chiasson, J. L. ; Garrido, M. ; MacKinnon, I. ; Rao, P. V. ; Zinman, B. ; Jung, H. ; Joldersma, L. ; Bosch, J. ; Yusuf, S. (2010) Long-term effect of rosiglitazone and/or ramipril on the incidence of diabetes Diabetologia, 54 (3). pp. 487-495. ISSN 0012-186X

Full text not available from this repository.

Official URL: http://www.springerlink.com/content/l8447t23587r25...

Related URL: http://dx.doi.org/10.1007/s00125-010-1985-4


Aims/hypothesis: The Diabetes Reduction Assessment with Ramipril and Rosiglitazone Medication (DREAM) trial reported that 3 years of therapy with rosiglitazone reduced the primary outcome of diabetes or death by 60%. Here we investigated whether an effect on diabetes prevention persists more than 1.5 years after therapy has been discontinued. Methods: The DREAM On passive follow-up study was conducted at 49 of the 191 DREAM sites. Consenting participants were invited to have a repeat OGTT 1-2 years after active therapy ended. A diagnosis of diabetes at that time was based on either a fasting or 2 h plasma glucose level of ≥7.0 mmol/l or ≥11.1 mmol/l, respectively, or a confirmed diagnosis by a non-study physician. Regression to normoglycaemia was defined as a fasting and 2 h plasma glucose level of <6.1 mmol/l and <7.8 mmol/l, respectively. Results: After a median of 1.6 years after the end of the trial and 4.3 years after randomisation, rosiglitazone participants had a 39% lower incidence of the primary outcome (hazard ratio [HR] 0.61, 95% CI 0.53-0.70; p<0.0001) and 17% more regression to normoglycaemia (95% CI 1.01-1.34; p=0.034). When the analysis was restricted to the passive follow-up period, a similar incidence of both the primary outcome and regression was observed in people from both treatment groups (HR 1.00, 95% CI 0.81-1.24 and HR 1.14, 95% CI 0.97-1.32, respectively). Similar effects were noted when new diabetes was analysed separately from death. Ramipril did not have any significant long-term effect. Conclusions/interpretation: Time-limited exposure to rosiglitazone reduces the longer term incidence of diabetes by delaying but not reversing the underlying disease process.

Item Type:Article
Source:Copyright of this article belongs to Springer.
Keywords:Diabetes Prevention; Legacy Effect; Ramipril; Randomised; Rosiglitazone
ID Code:81540
Deposited On:06 Feb 2012 03:45
Last Modified:06 Feb 2012 03:45

Repository Staff Only: item control page