Association of visceral and subcutaneous fat with glucose intolerance, insulin resistance, adipocytokines and inflammatory markers in Asian Indians (CURES-113)

Indulekha, Karunakaran ; Anjana, Ranjith Mohan ; Surendar, Jayagopi ; Mohan, Viswanathan (2011) Association of visceral and subcutaneous fat with glucose intolerance, insulin resistance, adipocytokines and inflammatory markers in Asian Indians (CURES-113) Clinical Biochemistry, 44 (4). pp. 281-287. ISSN 0009-9120

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Official URL: http://www.sciencedirect.com/science/article/pii/S...

Related URL: http://dx.doi.org/10.1016/j.clinbiochem.2010.12.015

Abstract

Objectives: The aim of the study was to assess the association between visceral and subcutaneous fat with glucose intolerance, adipocytokines, inflammatory markers and carotid IMT in Asian Indians. Design and methods: Subjects with NGT (n = 85), IGT (n = 49) and T2DM (n = 93) were randomly selected from CURES. Total abdominal, visceral and subcutaneous fat were measured using Helical CT scan. Adiponectin, hs-CRP, TNF-α, oxidized LDL, visfatin and leptin and IMT and insulin resistance were assessed. Results: Total abdominal fat (p = 0.041) and the visceral fat (p = 0.039) but not subcutaneous fat progressively increased from NGT, IGT and T2DM subjects. With increasing quartiles of visceral fat, there was a significant increase in insulin resistance (p = 0.040); significant decrease in adiponectin (p = 0.043) and increase in TNF-α (p = 0.028), hs-CRP (p = 0.043), OX-LDL (p = 0.034) and visfatin (p = 0.040), and carotid IMT (p = 0.047) was observed. Conclusion: Visceral fat levels increased with increasing glucose intolerance and are associated with decreased levels of adiponectin and increased levels of hs-CRP, TNF-α, oxidized LDL, visfatin, HOMA-IR and IMT.

Item Type:Article
Source:Copyright of this article belongs to Elsevier Science.
Keywords:Visceral Fat; Subcutaneous Fat; Adiponectin; Leptin; hs-CRP; TNF-alpha; Oxidized LDL; Visfatin; Diabetes; South Asians
ID Code:81536
Deposited On:06 Feb 2012 03:52
Last Modified:06 Feb 2012 03:52

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