A model of translational research for diabetes prevention in low and middle-income countries: The Diabetes Community Lifestyle Improvement Program (D-CLIP) trial

Beth, Mary ; Ranjani, Harish ; Meyers, Gaya Celeste ; Mohan, Viswanathan ; Venkat Narayan, K. M. (2011) A model of translational research for diabetes prevention in low and middle-income countries: The Diabetes Community Lifestyle Improvement Program (D-CLIP) trial Primary Care Diabetes . ISSN 1751-9918

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Official URL: http://www.primary-care-diabetes.com/article/S1751...

Related URL: http://dx.doi.org/10.1016/j.pcd.2011.04.005

Abstract

Aims: The Diabetes Community Lifestyle Improvement Program (D-CLIP) aims to implement and evaluate in a controlled, randomized trial the effectiveness, cost-effectiveness, and sustainability of a culturally appropriate, low-cost, and sustainable lifestyle intervention for the prevention of type 2 diabetes mellitus in India. Methods: D-CLIP, a translational research project adapted from the methods and curriculum developed and tested for efficacy in the Diabetes Prevention Program, utilizes innovated methods (a step-wise model of diabetes prevention with lifestyle and metformin added when needed; inclusion of individuals with isolated glucose tolerance, impaired fasting glucose, and both; classes team-taught by professionals and trained community educators) with the goals of increasing diabetes prevention, community acceptability, and long-term dissemination and sustainability of the program. The study outcomes are: diabetes incidence (primary measure of effectiveness), cost-effectiveness, changes in anthropometric measures, plasma lipids, blood pressure, blood glucose, and HbA1c, Program acceptability and sustainability will be assessed using a mixed methods approach. Conclusion: D-CLIP, a low-cost, community-based, research program, addresses the key components of translational research and can be used as a model for prevention of chronic diseases in other low and middle-income country settings.

Item Type:Article
Source:Copyright of this article belongs to Elsevier.
Keywords:Type 2 Diabetes Mellitus; Translational Research; Lifestyle Intervention
ID Code:81519
Deposited On:06 Feb 2012 03:54
Last Modified:06 Feb 2012 03:54

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