Increased levels of serum granulocyte-macrophage colony-stimulating factor is associated with activated peripheral dendritic cells in Type 2 diabetes subjects (CURES-99)

Surendar, Jayagopi ; Mohan, Viswanathan ; Pavankumar, Nathella ; Babu, Subash ; Aravindhan, Vivekanandhan (2011) Increased levels of serum granulocyte-macrophage colony-stimulating factor is associated with activated peripheral dendritic cells in Type 2 diabetes subjects (CURES-99) Diabetes Technology & Therapeutics, 14 (4). pp. 344-349. ISSN 1520-9156

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Official URL: http://online.liebertpub.com/doi/abs/10.1089/dia.2...

Related URL: http://dx.doi.org/10.1089/dia.2011.0182

Abstract

Background: Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a pro-inflammatory cytokine with growth factor-like properties for monocytes and dendritic cells (DCs). In the present study, serum GM-CSF levels and the activation status of DCs were studied in type 2 diabetes mellitus (T2DM) subjects. Methods: Study subjects were recruited from the Chennai Urban Rural Epidemiology Study. Healthy controls (n=45) and T2DM patients (n=45) were included in the study. Serum levels of GM-CSF, interleukin-1β, interleukin-6, and tumor necrosis factor-a were measured. Enumeration of circulating DCs (myeloid [m] and plasmocytoid [p]) and its surface antigen expression were quantified by flow cytometry. Results: The serum GM-CSF levels were significantly higher among diabetes subjects compared with subjects without diabetes and showed a positive correlation with glycated hemoglobin (r=0.208, P=0.018). The serum GM-CSF levels were lower in subjects on combined insulin and oral hypoglycemic agents (OHA) treatment (1.09 pg/mL) compared with those taking OHA alone (1.9 pg/mL). The increased GM-CSF levels were associated with the activated phenotype of mDCs and pDCs, as determined by up-regulation of the lineage markers. Conclusion: The activated state of mDCs and pDCs seen among diabetes subjects might be due to the increased levels of GM-CSF and other pro-inflammatory cytokines.

Item Type:Article
Source:Copyright of this article belongs to Mary Ann Liebert.
ID Code:81495
Deposited On:06 Feb 2012 04:05
Last Modified:18 Jun 2012 05:13

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