Ravindranath, V. ; Burka, L. T. ; Boyd, M. R. (1984) Reactive metabolites from the bioactivation of toxic methylfurans Science, 224 (4651). pp. 884-886. ISSN 0036-8075
Full text not available from this repository.
Official URL: http://www.sciencemag.org/content/224/4651/884.sho...
Related URL: http://dx.doi.org/10.1126/science.6719117
Abstract
An important mechanism of toxicity of furans involves the cytochrome P-450 monooxygenase-catalyzed bioactivation of the compound in situ directly within the target tissues to highly reactive electrophilic products. The unsaturated aldehydes acetylacrolein and methylbutenedial have been identified as the principal reactive intermediates of 2- and 3-methylfuran, respectively, that are produced and bound covalently to tissue macromolecules in hepatic and pulmonary microsomal systems in vitro.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to American Association for the Advancement of Science. |
| ID Code: | 81191 |
| Deposited On: | 04 Feb 2012 11:14 |
| Last Modified: | 04 Feb 2012 11:14 |
Repository Staff Only: item control page
