Familial aggregation in tropical fibrocalculous pancreatic diabetes

Mohan, V. ; Chari, S. T. ; Hitman, G. A. ; Suresh, S. ; Madanagopalan, N. ; Ramachandran, A. ; Viswanathan , M. (1989) Familial aggregation in tropical fibrocalculous pancreatic diabetes Pancreas, 4 (6). pp. 690-693. ISSN 0885-3177

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There is very little information on the genetic factors associated with fibrocalculous pancreatic diabetes (FCPD). Ninety-eight first-degree relatives of FCPD patients were subjected to detailed studies, which included glucose tolerance tests, x-ray films of the abdomen, ultrasonography, and studies of exocrine pancreatic function. The study shows that there is a familial aggregation of FCPD with evidence of vertical transmission of the disease from parent to offspring in some families. Routine screening of families of FCPD probands helped to pick up cases in the stage of impaired glucose tolerance. There is heterogeneity in FCPD with respect to familial factors. Some families show marked familial aggregation of FCPD while in others the disease occurs either sporadically or in association with other family members who have abnormal glucose handling.

Item Type:Article
Source:Copyright of this article belongs to Lippincott Williams and Wilkins.
ID Code:80494
Deposited On:01 Feb 2012 09:39
Last Modified:01 Feb 2012 09:39

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