Ramachandran, A. ; Snehalatha, C. ; Premila, L. ; Mohan, V. ; Viswanathan, M. (1990) Familial aggregation in type 1 (insulin dependent) diabetes mellitus: a study from South India Diabetic Medicine, 7 (10). pp. 876-879. ISSN 0742-3071
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Official URL: http://onlinelibrary.wiley.com/doi/10.1111/j.1464-...
Related URL: http://dx.doi.org/10.1111/j.1464-5491.1990.tb01322.x
Abstract
An analysis of 617 Type 1 (insulin-dependent) diabetic patients from 587 families was made. In 33 families (5.6%) there was more than one Type 1 diabetic patient. In 98 families (16.7%) positive family history of Type 2 (non-insulin-dependent) diabetes was present. There was a linear correlation between the age at diagnosis of the proband and that of the sibling (r = 0.73, p < 0.001) in the Type 1 multiplex families. The risk of Type 1 diabetes in relatives was found to be 2.7% by Li Mantel estimate, which is lower than that reported among Europeans. The cumulative risk was higher (p < 0.001) in the relatives of Type 1 diabetic patients with age at diagnosis.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to John Wiley and Sons. |
| Keywords: | Type 1 (insulin-dependent) Diabetes; Familial Aggregation; Family History of Diabetes; Risk of Diabetes India |
| ID Code: | 80483 |
| Deposited On: | 01 Feb 2012 09:44 |
| Last Modified: | 01 Feb 2012 09:44 |
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