Sinha, Sutapa ; Chattopadhayay, S. ; Bhattacharya, S. K. ; Nair, G. B. ; Ramamurthy, T. (2004) An unusually high level of quinolone resistance associated with type II topoisomerase mutations in quinolone resistance-determining regions of Aeromonas caviae isolated from diarrhoeal patients Research in Microbiology, 155 (10). pp. 827-829. ISSN 0923-2508
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Official URL: http://www.sciencedirect.com/science/article/pii/S...
Related URL: http://dx.doi.org/10.1016/j.resmic.2004.06.008
Abstract
We examined 158 strains belonging to different Aeromonas species isolated from hospitalized acute diarrhoea cases for susceptibility to quinolones. Compared to other species, a high percentage of the A. caviae strains were resistant to ciprofloxacin and norfloxacin. Based on MIC values, 6 A. caviae strains were selected and the nucleotide sequences for the quinolone-resistant-determining regions (QRDRs) of gyrA, gyrB and parC genes were analysed. In resistant strains, double mutations (Ser83→Ile and Asp87→Asn) and a single mutation (Ser80→Ile) were detected in the QRDR of gyrA and parC, respectively.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| Keywords: | Aeromonas Caviae; Quinolones; Resistance; Mutations |
| ID Code: | 80465 |
| Deposited On: | 01 Feb 2012 10:16 |
| Last Modified: | 01 Feb 2012 10:16 |
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