Does oxidant stress play a role in diabetic retinopathy?

Rema, Mohan ; Mohan, V. ; Bhaskar, Anusha ; Radha Shanmugasundaram , K. (1995) Does oxidant stress play a role in diabetic retinopathy? Indian Journal of Ophthalmology, 43 (1). pp. 17-21. ISSN 0301-4738

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The role of oxidant stress in the causation of chronic tissue damage is being increasingly recognized. Oxidant stress is usually countered by abundant supply of antioxidants. If concomitant antioxidant deficiency occurs, oxidant stress may produce tissue damage. We took up a study on antioxidant status in non-insulin dependent diabetes mellitus (NIDDM) patients with and without retinopathy and compared them with a control non-diabetic group. The levels of superoxide dismutase (SOD) were significantly reduced in all diabetic patients, i.e., those with and without retinopathy. However, the lowest levels were found in the diabetic patients with retinopathy. Vitamin E and vitamin C levels were also markedly lower in the diabetic patients. There was a paradoxical rise in the catalase and glutathione peroxidase (GPx) in the diabetic patients with retinopathy. This may be a compensatory mechanism by the body to prevent tissue damage by increasing the levels of the two alternative antioxidant enzymes.

Item Type:Article
Source:Copyright of this article belongs to Medknow Publications.
Keywords:Non-insulin Dependent Diabetes Mellitus; Antioxidant Status; Superoxide Dismutase; Catalase; Vitamin E; Vitamin C
ID Code:80296
Deposited On:31 Jan 2012 11:21
Last Modified:31 Jan 2012 11:21

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