Long-term ingestion of cassava (tapioca) does not produce diabetes or pancreatitis in the rat model

Mathangi, Damal C. ; Deepa, Raj ; Mohan, Viswanathan ; Govindarajan, Meera ; Namasivayam, Ambalavanan (2000) Long-term ingestion of cassava (tapioca) does not produce diabetes or pancreatitis in the rat model International Journal of Gastrointestinal Cancer, 27 (3). pp. 203-208. ISSN 1537-3649

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Official URL: http://www.springerlink.com/content/t26683626m6v10...

Related URL: http://dx.doi.org/10.1385/IJGC:27:3:203

Abstract

Cassava (tapioca, manihot) is consumed as a staple food in some developing countries. The intake of cassava has been linked to several diseases including fibrocalculous pancreatic diabetes (tropical calcific pancreatitis). There are few long-term studies on the effect of cassava ingestion on the pancreas in animal models. This article reports on the long-term (up to 1 yr) effects of cassava in the rat model. We found that cassava did not produce diabetes in the rat even after a year of cassava feeding. There were transient changes in serum insulin and lipase levels, but the significance of these findings are not clear. There was no histopathological evidence of either acute or chronic pancreatitis, but there were changes of toxic hepatitis in the liver. In conclusion, chronic cassava ingestion up to a year does not lead to either diabetes or chronic pancreatitis in the rat model.

Item Type:Article
Source:Copyright of this article belongs to Springer.
Keywords:Cassava; Tapioca; Fibrocalculous Pancreatitis; Tropical Chronic Pancreatitis; Diabetes; Serum Insulin; Serum Lipase; Rat
ID Code:80258
Deposited On:31 Jan 2012 11:31
Last Modified:31 Jan 2012 11:31

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