Absence of association between serum homocysteine levels and coronary artery disease in South Indian males

Deepa, R. ; Velmurugan, K. ; Saravanan, G. ; Karkuzhali, K. ; Dwarakanath, V. ; Mohan, V. (2001) Absence of association between serum homocysteine levels and coronary artery disease in South Indian males Indian Heart Journal, 53 (1). pp. 44-47. ISSN 0019-4832

Full text not available from this repository.

Abstract

Background: Asian Indians are reported to have a very high prevalence of premature coronary artery disease. However, traditional risk factors do not explain this excess of coronary artery disease. Elevated levels of homocysteine are reported to be associated with coronary artery disease among Europeans. This study looked at the association of serum homocysteine levels with coronary artery disease in South Indians. Methods and results: Four groups of patients were studied: Group 1 consisted of healthy nondiabetic subjects without coronary artery disease (n=18): Group 2 consisted of nondiabetic subjects with coronary artery disease (n=21); Group 3 consisted of type 2 diabetic patients without coronary artery disease (n=18) and Group 4 consisted of type 2 diabetic patients with coronary artery disease (n=20). The mean homocysteine value was 12.4±3.4 micromol/L in Group 1; 12.6±4.6 micromol/L in Group 2; 10.1±4.4 micromol/L in Group 3; and 10.4±3.9 micromol/ L in Group 4. There was no significant difference in the homocysteine levels between the groups studied. The prevalence of hyperhomocysteinemia, defined as a level of 17.1 micromol/L (the 95th percentile for serum homocysteine in the control group) was not significantly different among the groups. Conclusions: Elevated serum homocysteine levels are not associated with coronary artery disease in South Indian male subjects with or without diabetes. However, the results must be interpreted with caution because of the small numbers studied.

Item Type:Article
Source:Copyright of this article belongs to Cardiological Society of India.
ID Code:80252
Deposited On:31 Jan 2012 11:33
Last Modified:31 Jan 2012 11:33

Repository Staff Only: item control page