Novel structural motifs in telomere DNA sequences

Bhavesh, Neel S. ; Patel, Prasanta K. ; Hosur, Ramakrishna V. (2004) Novel structural motifs in telomere DNA sequences Proceedings of the Indian National Science Academy - Part A: Physical Sciences, 70 (4). pp. 605-613. ISSN 0370-0046

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Maintenance of linear DNA in chromosomes during replication and other biological function of telomeri DNA and its associated proteins have been widely investigated in recent years. Advances in NMR methodologies have led to characterization of many telomeric repeat sequences, which have exhibited a great degree of structural polymorphism. Many new structural motifs and folding topologies have been discovered in telomeric DNA repeats. A number of proteins have also been identified which have specific binding for higher order structures formed by telomeric DNA repeat sequences. In this review, we have discussed teh various new motifs experimentally observed in telomeric repeat sequences.

Item Type:Article
Source:Copyright of this article belongs to Indian National Science Academy.
Keywords:Telemere; DNA; Quadruplex; Tetrad; I-Motif; NMR
ID Code:80104
Deposited On:31 Jan 2012 04:21
Last Modified:18 May 2016 22:14

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