Traffic of interacting ribosomes: effects of single-machine mechanochemistry on protein synthesis

Basu, Aakash ; Chowdhury, Debashish (2007) Traffic of interacting ribosomes: effects of single-machine mechanochemistry on protein synthesis Physical Review E, 75 (2). 021902_1-021902_11. ISSN 1063-651X

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Official URL: http://pre.aps.org/abstract/PRE/v75/i2/e021902

Related URL: http://dx.doi.org/10.1103/PhysRevE.75.021902

Abstract

Many ribosomes simultaneously move on the same messenger RNA (mRNA), each synthesizing separately a copy of the same protein. In contrast to the earlier models, here we develop a "unified" theoretical model that not only incorporates the mutual exclusions of the interacting ribosomes, but also describes explicitly the mechanochemistry of each of these macromolecular machines during protein synthesis. Using analytical and numerical techniques of nonequilibrium statistical mechanics, we analyze the rates of protein synthesis and the spatiotemporal organization of the ribosomes in this model. We also predict how these properties would change with the changes in the rates of the various chemomechanical processes in each ribosome. Finally, we illustrate the power of this model by making experimentally testable predictions on the rates of protein synthesis and the density profiles of the ribosomes on some mRNAs in E-coli.

Item Type:Article
Source:Copyright of this article belongs to American Physical Society.
ID Code:8009
Deposited On:25 Oct 2010 09:46
Last Modified:16 May 2016 18:06

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